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FLASH GENE
Symbol SRR contributors: mct - updated : 01-07-2011
HGNC name serine racemase
HGNC id 14398
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 2477 - 340 - 2000 11054547
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Nervousbraindiencephalonamygdala highly Homo sapiens
 braindiencephalonthalamus highly Homo sapiens
 brainforebraincerebral cortex   Homo sapiens
Reproductivefemale systembreastmammary gland highly Homo sapiens
Visualeyeretina  moderately Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousastrocyte Homo sapiens
Nervousneuron Homo sapiens
Nervouspyramidal cell Homo sapiens
VisualMuller cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period perinatal
Text
  • high levels detected in retina during the early postnatal period, but diminishing considerably in the mature retina (
  • PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    N terminal pyridoxal phosphate attachment sequence
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • catalyzing synthesis of D serine from L serine
  • playing a role in neuronal activity and a potential biological role in the regulation of N-methyl-D-aspartate (NMDA) receptor activity in these peripheral organs as well
  • important contribution of neuronal D-serine during retinal development
  • involved in the regulation of synaptic plasticity, neural network formation, and neurodegenerative disorders
  • plays a key role in the regulation of brain functions under physiological and pathological conditions via the production of the neuromodulator D-serine
  • responsible for the synthesis of D-serine, an endogenous co-agonist for N-methyl-D-aspartate receptor-type glutamate receptors (NMDARs)
  • physiologic coagonist at NMDA receptors, having a role in NMDA receptor-mediated neurotoxicity and stroke
  • catalyzes the racemization between l- and d-serine
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    aberrant Srr function and diminished d-serine may contribute to schizophrenia pathogenesis
    constitutional     --over  
    increased expression in the hippocampus in schizophrenia (
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    psychiatryschizophrenia 
    promising target for the treatment of disorders related to NMDAR dysfunction
    ANIMAL & CELL MODELS
  • mutant Srr mice displayed behaviors relevant to schizophrenia, including impairments in prepulse inhibition, sociability and spatial discrimination