basic FUNCTION
| required to support proliferation and self-renewal of stem cells by regulating the translation of key |
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transcripts |
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could also play an important role in translational regulation of embryogenesis and cell development and differentiation |
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regulates translation of specific mRNAs in morphogenesis and germ-line development of the flies by binding nucleotide motifs GUUGU (A) and AUUGUA (B) in 3'untranslated regions |
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plays crucial roles in fertility of many organisms acting as a repressor of translation, and causing infertility when mutated (Kusz 2007) |
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it is improbable that mutations of this gene significantly contribute to male infertility |
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implicated in controlling germ cell development through interactions with the RNA binding proteins deleted in azoospermia (DAZ), DAZ-like (DAZL) and BOULE |
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role in dendrite morphogenesis, synapse function, and translational control |
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does not repress differentiation of adipose-derived stem cell (ASC) but rather is involved in the positive control of ASCs division and proliferation |
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essential for synapse formation and maintenance in many species |
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RNA binding translational repressor |
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PUM2 interacting with transcripts encoding proteins specific to subsets of hippocampal synapses could be related with learning and memory processes in mammals |
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PUM1, PUM2 regulates the translation of the voltage-gated sodium conductance, leading to a concomitant adjustment in action potential firing |
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PUM1, PUM2 are potent repressors that serve important roles in stem cell maintenance, neurological processes, and embryonic development |
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PUM1, PUM2 increased double-stranded (ds) RNA binding affinity of DHX58, and likely facilitates viral RNA recognition by DHX58 through its chaperon-like function |
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plays an important role in translational regulation in the central nervous system (CNS), particularly for dendrite outgrowth and neuronal excitability |
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distinct roles of individual mammalian PUM1, PUM2 in embryonic stem cells (ESCs), having essential functions in ESC pluripotency and embryogenesis |