basic FUNCTION
| transducing the growth promoting signal of IL21 |
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being important for the proliferation and differentiation of T cells,B cells and natural killer (NK) cells |
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involved in the activation of multiple downstream signaling molecules including JAK1, JAK3, STAT1 and STAT3 by ligand binding |
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important amplifier of alternative macrophage activation |
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essential function in the development of pathogen-induced Th2 responses, which may have relevance in therapies for both inflammatory and chronic fibrotic diseases |
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playing a role in regulating immunoglobulin production |
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PTH and IL21R both have potential biologic functions important to bone metabolism |