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FLASH GENE
Symbol IL21R contributors: mct - updated : 24-03-2016
HGNC name interleukin 21 receptor
HGNC id 6006
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 splicing 4512 59.1 538 - 2000 11081504
  • differing in the 5' UTR as compared to variant 2 and 3
  • encoding the same protein
  • 9 splicing 4865 59.1 538 - 2000 11081504
  • differing in the 5' UTR as compared to variant 1
  • encoding the same protein
  • 10 splicing 5006 - 560 - 2000 11081504
  • differing in the 5' UTR as compared to variant 1
  • encoding the same protein
  • EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunespleen   highly
     thymus   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    cell lineage
    cell lines lymphoma
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a fibronectin type III domain
  • conjugated GlycoP
    mono polymer heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • type I cytokine receptor family
  • type 4 subfamily
  • CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type I membrane protein
    basic FUNCTION
  • transducing the growth promoting signal of IL21
  • being important for the proliferation and differentiation of T cells,B cells and natural killer (NK) cells
  • involved in the activation of multiple downstream signaling molecules including JAK1, JAK3, STAT1 and STAT3 by ligand binding
  • important amplifier of alternative macrophage activation
  • essential function in the development of pathogen-induced Th2 responses, which may have relevance in therapies for both inflammatory and chronic fibrotic diseases
  • playing a role in regulating immunoglobulin production
  • PTH and IL21R both have potential biologic functions important to bone metabolism
  • CELLULAR PROCESS cell life, differentiation
    cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    IL21/IL21R pathway is a critical component of the memory B cell response
    a component
  • forming a heterodimeric receptor complex with the common gamma-chain
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to JAK1
  • WSB1 associating with the middle part of intracytoplasmic region of IL21R and enhances the maturation of IL21R from N-linked glycosylated form to fully glycosylated mature form
  • is produced predominantly by activated CD4+ T cells and has pleiotropic effects on immunity via IL21R
  • cell & other
    REGULATION
    Other CASP8 cleavage of IL21R is a negative feedback regulator of IL21 signaling
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --other  
    IL21 and IL21R expression in lymphocytes and neurons in multiple sclerosis brain
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    immunologyinflammatory 
    blocking IL21R signaling may have a therapeutic potential in inflammatory bowel disease
    ANIMAL & CELL MODELS