may have a physiological role in spermatogenesis and/or human sperm cell function--especially in capacitation and/or acrosome reaction
protects podocytes from apoptosis, and likely this is mediated by stabilization of CDKN1A
activators of CDK5, CDK5R1, and CCNI are not required for normal kidney function, but, they play pivotal coordinated roles in maintaining podocyte survival during stress states in disease
has a role in the regulation of cell cycle progression
CELLULAR PROCESS
PHYSIOLOGICAL PROCESS
PATHWAY
metabolism
signaling
a component
INTERACTION
DNA
RNA
small molecule
protein
CDK5 is activated by both CCNI and the noncyclin activator CDK5R1 in terminally differentiated cells such as kidney podocytes and neurons
interaction between Cyclin I and CDK5 was detected in cells overexpressed with both proteins
predominance of CCNI mediates the nuclear localization of CDK5, whereas the predominance of CDK5R1 results in a membranous localization of CDK5