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FLASH GENE
Symbol ASPN contributors: mct - updated : 17-08-2007
HGNC name asporin
HGNC id 14872
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 2480
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
 vesselsaorta   
Digestiveesophagus   highly
 intestinesmall intestine  highly
Reproductivefemale systemuterus  highly
Respiratorylung   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  highly
Connectivebone   
Connectivecartilage   
Connectivedenseligamentperidontal 
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal leucine-rich repeat and cysteine domain, playing an important role in the PLAP1/asporin
  • BMP2 interaction
  • one unique stretch of aspartic acid residues
  • HOMOLOGY
    interspecies homolog to murine Aspn
    intraspecies homolog to decorin
    Homologene
    FAMILY
  • class I SLRPs (small leucine-rich repeat proteoglycan) family
  • CATEGORY adhesion
    SUBCELLULAR LOCALIZATION extracellular
    text extracellular matrix
    basic FUNCTION
  • involved in the mineralized matrix formation in periodontal ligament
  • suppressing TGFB-mediated expression of aggrecan (ACAN) and type II collagen (COL2A1)
  • acting as a negative regulator of chondrogenesis by inhibiting TGFB function
  • negative regulator of cytodifferentiation and mineralization probably by regulating BMP-2 activity
  • blocks chondrogenesis and inhibits TGF1-induced expression of matrix genes and the resulting chondrocyte phenotypes
  • negatively regulates chondrogenesis in articular cartilage by blocking the TGF-/receptor interaction on the cell surface and inhibiting the canonical TGF-/Smad signal
  • critical regulator of TGF- in articular cartilage and thus plays an essential role in cartilage homeostasis and OA pathogenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with TGFB1
  • interacting with BMP2 (inhibits BMP2-induced differentiation of periodontal ligament cells resulting from inactivation of the BMP2 signaling pathway)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to osteoarthritis in Japanese population
  • to lumbar disc degeneration (LDD)
  • Variant & Polymorphism other
  • allele D14 osteoarthritis susceptible, association of the ASPN D14 allele and knee osteoarthritis
  • allele D13 osteoarthritis protective
  • allele D14 significantly associated with LDD in Chinese and Japanese individuals
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS