basic FUNCTION
| protein serine/threonine kinase activity |
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may function in both a kinase-dependent as well as a kinase-independent manner to activate NFkappaB |
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crucial modulator of epidermal differentiation, and important and unique functions in keratinocytes of normal and wounded skin |
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potentially functioning in the epidermis through PKC-specific signaling pathways to regulate differentiation and inflammation |
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important regulator of epidermal morphogenesis during embryonic development |
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RIPK4 requires IKBKB for the induction of the canonical NFKB pathway |
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RIPK4 and CHUK might function via closely related pathways to promote keratinocyte differentiation and epithelial growth |
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with RIPK4, ZBTB21 has potential role in the pathogenesis of Congenital heart defect (CHD) in Down syndrome (DS) |
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RIPK4 and IRF6 function as a cell-intrinsic signaling axis to regulate keratinocyte differentiation |
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is a key regulator of keratinocyte differentiation |
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potential role for RIPK4 in the regulation of keratinocyte cornification |
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key regulator of keratinocyte differentiation, cutaneous inflammation, and cutaneous wound repair |
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RIPK4 can play a dual role as both a tumor promoter and a tumor suppressor in different tumor types |
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RIPK4 is associated with tumor metastasis and implicated in the regulation of the WNT signaling pathway |