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FLASH GENE
Symbol MMP26 contributors: mct/npt - updated : 08-04-2010
HGNC name matrix metalloproteinase 26
HGNC id 14249
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 998 - 261 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale systemuterus  specific
cell lineage
cell lines lymphoma cells, tumor cell lines, endometrial tumors
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a signal peptide, involved in enzyme latency
  • a prodomain
  • a catalytic domain with the zinc binding site and an adjacent threonine residue
  • lacking the hinge region and hemopoxin-like (PEX) C terminal domain
  • conjugated GlycoP , MetalloP
    isoforms Precursor
    HOMOLOGY
    intraspecies homolog to macrophage metalloelastase,MMP3,MMP12
    Homologene
    FAMILY
  • stromelysin subclass of MMP family
  • peptidase M10A family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
    text extracellular matrix
    basic FUNCTION
  • proteolytic enzyme in the extracellular matrix tissue remodeling events associated with tumor progression
  • MMP21, MMP26 are not only associated with cancer but may be important in connective tissue remodelling and pathobiology of various benign skin disorders
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, cofactor,
  • Zn2+
  • Ca2+
  • protein
  • cleaved gelatin, alpha-protein inhibitors, fibrinogen
  • progelatinase B (activation)
  • binding TIMPs in a 1:1 stoechiometry
  • interacting with STRAP (serine threonine receptor-associated protein (STRAP) is a further protein recruited to the MMP28 promoter and acting functionally with Sp1) (Swingler 2010)
  • HOXA10-mediated expression of MMP26 promotes embryo adhesion during the process of embryonic implantation.
  • cell & other
    REGULATION
    activated by proteinases
    induced by histone deacetylase (HDAC) inhibitors and this effect is mediated through the GT-box (Swingler 2010)
    inhibited by TIMPs and TFPI2
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in Merkel cell carcinoma with larger tumors and with poor prognosis(Suomela 2009)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS