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FLASH GENE
Symbol SOX18 contributors: mct - updated : 21-03-2015
HGNC name SRY (sex determining region Y)-box 18
HGNC id 11194
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 1718 - 384 - 2007 17603017
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheartventricle  predominantly
Digestiveintestinesmall intestinejejunum  
 liver    
 stomach   highly
Lymphoid/Immunespleen    
Nervousnervecranial nerve  highly
Reproductivefemale systemplacenta  highly
 female systemovary  highly
Respiratorylung    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text brain
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N-terminal high-mobility group DNA binding and a central transactivation domain
  • a 9AA transactivation motif that mediates the interaction with the transcriptional cofactor TAF9 and with general co-factors
  • a C-terminal region of unknown function with three blocks that are highly conserved within a subgroup of the Sox family, and the central so-called charged block comprises an additional strong transactivating domain.
  • HOMOLOGY
    interspecies homolog to murine Sox18
    homolog to C.elegans k08a8.2
    Homologene
    FAMILY SRY-related HMG box family of transcription factors
    CATEGORY DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • involved in the transactivation of transcription
  • involved in vascular cell growth and this transcription factor may play a role in atherosclerosis
  • involved in the development or function of blood vessels, the lymphatic system and hair follicles (Downes 2009)
  • critical role for SOX18 in the maturation rather than the early modeling of the blood vasculature (Downes 2009)
  • acts as a transcriptional activator of genes required for vascular structural integrity and the recruitment of pericytes to developing blood vessels (Downes 2009)
  • plays a role in angiogenesis, including lymphangiogenesis, where it is upregulated by growth factors and directs the expression of genes encoding, e.g., guidance molecules and a matrix metalloproteinase
  • FIGF -mitogen-activated protein kinase kinase-extracellular signal-regulated kinase signaling modulates SOX18-mediated transcription, functioning at least in part by enhancing nuclear concentration and transcriptional activity in vascular endothelial cells
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding to the 5'-AACAAAG-3' consensus sequence
    RNA
    small molecule
    protein
  • interacting with CLDN5 (SOX18 involved in the regulation of CLDN5 gene expression in an endothelial-specific and cell density-dependent manner, play a nonredundant role in the formation of the endothelial barrier) (Fontijn 2008)
  • SOX18 is a novel target gene regulated by EGR1 transcription factor, thus providing the first functional link between two transcription factors previously shown to be involved in the control of angiogenesis
  • MMP7 is a direct SOX18 target gene as well as other potential candidates including guidance molecules
  • TNF-induced down-regulation of SOX18 in endothelial cells is dependent on NFKB
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) HLTS
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Sox18/Vegfd double but not single knockout mice displayed dramatic vascular development defects