Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol SH3GLB2 contributors: mct/npt - updated : 21-10-2014
HGNC name SH3-domain GRB2-like endophilin B2
HGNC id 10834
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 - 2323 - 404 - 2001 11161816
12 - 1763 44 395 - 2001 11161816
11 - 2296 44 395 - 2001 11161816
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrainbasal nucleicaudate nucleus highly
 braindiencephalonthalamus highly
 brainhindbraincerebellum highly
 spinal cord    
Skin/Tegumentskin    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier/lining   
Nervouscentral   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text brain
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal sequence folded into an amphipathic alpha-helix in the membrane environment, and N-BAR domain
  • a coiled coil (dimerization) domain
  • C-terminal SH3 domain flanking a variable intermediate region, and PLEC is a molecular partner of SH3GLB2 SH3 domain
  • mono polymer homomer , heteromer , dimer
    HOMOLOGY
    interspecies ortholog to murine Spas-1
    intraspecies homolog to RING3 protein
    Homologene
    FAMILY
  • endophilin-related protein family
  • endophilin family of BAR and Src homology 3 domain-containing proteins
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • playing a regulatory role in synaptic vesicle recycling
  • functions in the perinuclear organization of intermediate filaments
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • homodimer and heterodimer with SH3GLB1
  • endophilin B2-plectin 1 complex functions as a membrane-anchoring device organizing and stabilizing the perinuclear network of vimentin filaments
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • BAX apoptotic inducer
  • interacts directly with plectin 1 and controls the perinuclear vimentin network
  • physical and functional links between SH3GLB2 and vimentin
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in gastric cancer
    tumoral     --over  
    in prostate cancer metastases
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target potentially attractive candidate target antigen for the development of antigen-targeted immunotherapies in humans
    ANIMAL & CELL MODELS