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FLASH GENE
Symbol TRAP1 contributors: mct - updated : 26-01-2022
HGNC name TNF receptor-associated protein 1
HGNC id 16264
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
17 - 2064 - 651 - 2005 16269234
15 - 2248 62 547 testis 2005 16269234
15 exons
19 - 2189 76 669 trachea 2005 16269234
19 exons
13 - 2309 54 469 - 2005 16269234
13 exons
18 - 2265 76 672 brain 2005 16269234
18 exons
18 - 2208 76 672 placenta 2005 16269234
18 exons
18 - 2310 79 704 - 2005 16269234
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveliver    
 mouthtongue  highly
Endocrinepancreas    
Nervousbrain    
Reproductivefemale systemuteruscervix highly
 female systemplacenta   
Respiratorylung    
Urinarykidney    
Visualeye   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text amnion cells
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mitochondrial localization sequence in the N terminus
conjugated PhosphoP
HOMOLOGY
interspecies homolog to murine Trap1 (88.5pc)
homolog to rattus Trap1 (88.5pc)
Homologene
FAMILY heat shock protein 90 (HSP90) chaperone family
CATEGORY chaperone/stress
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,mitochondria,inner
intracellular,cytoplasm,organelle,mitochondria,interspace
intracellular,cytoplasm,organelle,mitochondria,matrix
intracellular,cytoplasm,organelle,membrane
intracellular,nucleus,nucleoplasm
basic FUNCTION
  • exhibiting ATPase activity
  • might play a role in protecting mitochondria against damaging stimuli via decrease of reactive oxygen species generation
  • protecting cells from oxidative stress and apoptosis
  • mitochondrial survival factor differentially expressed in localized and metastatic prostate cancer compared with normal prostate
  • acts as a molecular chaperone to retinoblastoma protein (Rb) during cellular stress
  • controls cell cycle activity through the tumor necrosis factor pathways
  • mitochondrial chaperone with antioxidant and antiapoptotic functions, involved in multidrug resistance in colorectal carcinoma cells
  • likely reduces the hypertrophy and fibrosis induced by pressure overload through blocking TAK/P38, JNK, and AKT signaling pathways
  • is involved in the translational control of cancer cells through an attenuation of global protein synthesis
  • controls cell migration of cancer cells in metabolic stress conditions
  • TRAP1 is relevant in the control of the complex machinery that governs cell cycle progression and mitotic entry
  • molecular chaperone involved in the regulation of energetic metabolism in cancer cells
  • role of TRAP1 is to enhance or suppress oxidative phosphorylation
  • potential TRAP1 role in triggering the alternate energy metabolism in cancer cells
  • TRAP1 role in tumor metastasis, which is in addition to altered energy metabolism
  • it is involved in the assembly of the electron transport chain, and it favours the switch from oxidative phosphorylation to glycolysis
  • supports protein folding and contributes to the maintenance of mitochondrial integrity even under cellular stress
  • cellular regulator of mitochondrial bioenergetics, redox homeostasis, oxidative stress-induced cell death, apoptosis, and unfolded protein response (UPR) in the endoplasmic reticulum (ER)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP binding
  • protein
  • binding to the intracellular domain of tumor necrosis factor type 1 receptor
  • binding to RB1
  • interacting with cyclophilin D and negatively regulating mitochondrial cell death
  • Sorcin (SI) is a new TRAP1 interactor
  • a functional role of TRAP1 in maintaining mitochondrial integrity downstream of PINK1 and complex I deficits but parallel to or upstream of Parkin
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    prevented cardiac hypertrophy and fibrosis
    tumoral     --over  
    in several cancers, such as glioblastoma, colon, breast, prostate and lung cancers, often associated with drug resistance
    tumoral     --low  
    in specific tumors, such as ovarian, bladder and renal cancers, correlated with the worst prognoses and chemoresistance
    constitutional germinal mutation      
    autoinflammatory disease might be enhanced by bi-allelic mutations
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • potential of TRAP1 inhibitors as neuroprotective drugs
  • Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveprostate
    targeting the TRAP1 pathway with Gamitrinibs could be explored as novel molecular therapy in patients with advanced prostate cancer
    cancer  
    targeting TRAP1 constitutes likely a new antitumor approach
    cancerendocrinethyroid
    TRAP1 inhibition may be regarded as potential strategy to target specific features of thyroid carcinoma (TC), cell proliferation and resistance to apoptosis
    ANIMAL & CELL MODELS