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FLASH GENE
Symbol KIR3DL3 contributors: mct - updated : 23-03-2013
HGNC name killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3
HGNC id 16312
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 1691 - 410 - 2006 16391939
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/Immunenatural killer
Lymphoid/ImmuneT cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three immunoglobulin-like C2-type domains
  • an N-terminal signal sequence,
  • a transmembrane region lacking a positively charged residue
  • a long cytoplasmic tail containing an immunoreceptor tyrosine-based inhibitory motif (ITIM)
  • a KIR3DL interaction site seem to be largely conserved across the KIR3D family, with specificity differences mapping to a hotspot within the interaction interface
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY immunoglobulin superfamily
    CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type i membrane protein
    basic FUNCTION
  • not expressed in healthy individuals, but its expression might be induced under certain developmental or pathological situations
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component natural killer cell receptors cluster FLNKR@
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    repressed by RUNX3, (RUNX3 acting as a repressor of KIR expression in mature NK cells)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS