basic FUNCTION
| stimulating guanine nucleotide exchange on RhoA and RhoB, but not RhoC, RhoG, Rac1, or Cdc42 |
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stimulating the assembly of stress fibers and focal adhesions in a Rho kinase-dependent manner |
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playing a role in the determination of bone density in Caucasian women |
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role of ARHGEF3 in regulation of iron uptake and erythroid cell maturation |
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negatively regulates cell survival and skeletal myoblast differentiation by inhibiting CRTC2 and subsequently the Ser/Thr kinase AKT1 |
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regulator of CRTC2 signaling to AKT1 via a noncanonical mechanism |
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negatively regulates cell survival by suppressing CRTC2 and AKT1 |