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FLASH GENE
Symbol ARHGEF3 contributors: mct/npt - updated : 17-09-2013
HGNC name Rho guanine nucleotide exchange factor (GEF) 3
HGNC id 683
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 - 3649 - 558 - 2000 1087361
10 - 4065 - 532 - 2000 1087361
10 - 3612 59.8 526 - 2000 1087361
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestivestomach   highly
Endocrineparathyroid   highly
Nervousbrainforebraincerebral cortexfrontal cortexpredominantly Homo sapiens
Reproductivemale systemtestis  highly
Respiratoryrespiratory tracttrachea  highly
Urinarykidney    
Visualeyeanterior segment   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  highly
Muscularstriatumskeletal predominantly Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticplatelet
Lymphoid/Immunemacrophage
Nervousneuron
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N-terminal 125-AA fragment of ARHGEF3 is both necessary and sufficient for the inhibition of CRTC2
  • a diffuse B-cell lymphoma (Dbl) homology (DH) domain followed by
  • a pleckstrin homology (PH) domain
  • HOMOLOGY
    Homologene
    FAMILY
  • DBL family
  • CATEGORY regulatory , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • stimulating guanine nucleotide exchange on RhoA and RhoB, but not RhoC, RhoG, Rac1, or Cdc42
  • stimulating the assembly of stress fibers and focal adhesions in a Rho kinase-dependent manner
  • playing a role in the determination of bone density in Caucasian women
  • role of ARHGEF3 in regulation of iron uptake and erythroid cell maturation
  • negatively regulates cell survival and skeletal myoblast differentiation by inhibiting CRTC2 and subsequently the Ser/Thr kinase AKT1
  • regulator of CRTC2 signaling to AKT1 via a noncanonical mechanism
  • negatively regulates cell survival by suppressing CRTC2 and AKT1
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • regulator of transferrin uptake in erythroid cells, through activation of RHOA
  • activates RHOA and RHOB, but not RHOC, although their GTPase sequences are highly conserved
  • interacts with CRTC2 but not with MTOR, and this interaction is dependent on rictor
  • negatively regulates AKT1 phosphorylation and cell survival
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to postmenopausal osteoporosis
    Variant & Polymorphism SNP increasing the risk of postmenopausal osteoporosis
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS