potentially playing an active role in the circadian transcription
has a minimal role in the clock system
ARNTL2, ARNTL form a circadian paralog pair that is functionally redundant
CELLULAR PROCESS
nucleotide, transcription
PHYSIOLOGICAL PROCESS
circadian
PATHWAY
metabolism
signaling
signal transduction
a component
colocalizing and heterodimerizing with CLOCK, HF1A, NPAS2 (MOP4)
INTERACTION
DNA
binding to an E-box element (5'-GTGCAC-3')
RNA
small molecule
protein
CLOCK and HIF1A (heterodimeric partner of circadian and hypoxia factors)
interaction with ID2 (could potentially regulate aspects of both clock input and output through a time-of-day specific interaction with CLOCK and ARNTL1)