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FLASH GENE
Symbol KIR2DL5A contributors: mct/npt - updated : 28-02-2009
HGNC name killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A
HGNC id 16345
RNA
TRANSCRIPTS type messenger
text diversity due to alternative spliced isoforms and allelic variants
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- polyA site 9280 - - not expressed Vilches (2000)
- polyA site - - 375 - Vilches (2000)
- polyA site 10720 - - not expressed Vilches (2000)
8 - 1596 - 375 soluble Gomez-Lozano (2002)
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/HematopoieticNK cell
Lymphoid/Immunelymphocyte
Muscularmyocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two extracellular Ig-like domains of the D0 and D2 type and a long cytoplasmic tail with two immunoreceptor tyrosine based inhibitory motif (ITIM)
  • a putative AML1-binding site
  • HOMOLOGY
    intraspecies homolog to KIR2DL4
    Homologene
    FAMILY
  • immunoglobulin superfamily
  • CATEGORY immunity/defense , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • inhibiting the activity of NK cells thus preventing cell lysis
  • displays a variegated distribution on the surface of CD56(dim) NK cells (Estefanía 2007)
  • inhibitory receptor gathering a combination of genetic, structural, and functional features unique among KIR, which suggests that KIR2DL5 plays a specialized role in innate immunity (Estefanía 2007)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS