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FLASH GENE

Symbol

DAZ3

contributors: - updated : 22-11-2005

HGNC name	deleted in azoospermia 3
HGNC id	15965

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive male system testis     specific

cell lineage	predominantly in spermatogonia
cell lines
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	one RRM (RNA recognition motif)
	twelve 24 AA repeats of distinct forms(DAZ repeat)

HOMOLOGY

interspecies

ortholog to Drosophila boule

Homologene

FAMILY

CATEGORY

RNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION

germ-cell specific RNA-binding protein, involved in generation and maitenance of spermatogonial stem cell population

CELLULAR PROCESS	cell life, differentiation

PHYSIOLOGICAL PROCESS

reproduction/sex

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS