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FLASH GENE
Symbol AASS contributors: - updated : 05-05-2006
HGNC name aminoadipate-semialdehyde synthase
HGNC id 17366
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveliver   highly
Urinarykidney    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , dimer
HOMOLOGY
interspecies ortholog to yeast S.cerevisiae LYS1/LYS9
ortholog to murine Aass
Homologene
FAMILY
  • AlaDH/PNT family in the N-terminal section
  • saccharopine dehydrogenase family in the C-terminal section
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION . bifunctional enzyme catalyzing the first two steps in the mammalian lysine degradation pathway
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism aminoacid
    signaling
    lysine catabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by starvation
    ASSOCIATED DISORDERS
    corresponding disease(s) AASS , SCDD
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS