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FLASH GENE
Symbol PFDN4 contributors: npt/ - updated : 25-06-2008
HGNC name prefoldin subunit 4
HGNC id 8868
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 1383 15.18 134 - -
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Endocrinepancreas   highly
Nervousbrain    
Reproductivemale systemprostate   
Respiratorylung    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
cell lineage
cell lines
fluid/secretion
at STAGE
cell cycle     cell cycle, interphase, G1, S
PROTEIN
PHYSICAL PROPERTIES basic
STRUCTURE
motifs/domains
  • helix-loop-helix (HLH) motif
  • mono polymer heteromer , hexamer
    HOMOLOGY
    Homologene
    FAMILY
  • prefoldin beta subunit family
  • CATEGORY chaperone/stress , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • assisting in the correct folding of other proteins
  • transfering target proteins to cytosolic chaperonin (C-CPN)
  • promoting folding in an environment in which there are many competing pathways for nonnative proteins
  • playing a role during G1-S phase transition phase of the cell cycle
  • promoting folding of nascent polypeptide chain in an environment in which there are many competing pathways for nonnative proteins
  • CELLULAR PROCESS nucleotide, transcription
    protein, editing
    protein, post translation, folding
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterohexamer of two PFD-alpha type and four PFD-beta type subunits
  • INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • binding specifically to cytosolic chaperonin (C-CPN)binding to nascent polypeptide chain
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS