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FLASH GENE

Symbol

CLEC5A

contributors: mct - updated : 11-10-2011

HGNC name	C-type lectin domain family 5, member A
HGNC id	2054

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_013252 7 - 3524 21.5 188 - 2011 21094529

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive female system uterus       Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic monocyte Lymphoid/Immune macrophage

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a C-type lectin domain
	lectin-like fold similar to the natural-killer T-cell C-type lectin domains and associates with a 12-kDa DNAX-activating protein (DAP12)4 on myeloid cells

conjugated

GlycoP

mono polymer

homomer , dimer

HOMOLOGY

interspecies

homolog to murine Clecsf5

Homologene

FAMILY

C type lectin superfamily

CATEGORY

receptor membrane

SUBCELLULAR LOCALIZATION	plasma membrane
text	type II transmembrane protein

basic FUNCTION	involved in activation of myeloid cells in a calcium-dependent manner
	ABC-transporter involved in peptide export from the matrix space, having minor effects on nuclear gene expression
	important pattern recognition receptor in the context of dengue virus infection
	acting as a signaling receptor for proinflammatory cytokine release
	CLEC5A associates with both TYROBP and HCST in osteoclasts and bone marrow-derived macrophages, where HCST association depends almost entirely on TYROBP
	key regulator of synovial injury and bone erosion during autoimmune joint inflammation
	cell surface receptor strongly associated with the activation and differentiation of myeloid cells
	associates with its adaptor protein TYROBP to activate a signaling cascade resulting in activation of downstream kinases in inflammatory responses
	critical macrophage receptor for dengue virus

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

immunity/defense

text	anti-pathogen response

PATHWAY

metabolism

signaling

signal transduction

CLECSF5/DAP12 pathway

a component

homodimeric at the cell surface and binds to dengue virus serotypes 1-4

INTERACTION

DNA

RNA

small molecule

protein	associating with TYROBP
	interacts with dnax-activation protein 12

cell & other

interacts with the dengue virion

REGULATION

Other

down-regulated when monocytes differentiate into dendritic cells

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   mRNA expression was significantly lower in primary acute myeloid leukemia (AML) patient samples than in macrophages and granulocytes from healthy donors

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed immunology autoimmune articular may be a therapeutic target for treatment of immune-mediated skeletal disorders

ANIMAL & CELL MODELS