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FLASH GENE
Symbol BANP contributors: mct/npt - updated : 08-04-2009
HGNC name BTG3 associated nuclear protein
HGNC id 13450
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
12 splicing 2230 51 469 - Birot, Singh (2009)
13 splicing 2296 53.4 491 - Birot, Singh (2009)
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivepharynx   highly
Lymphoid/Immunespleen   highly
Reproductivefemale systembreast   
 female systemplacenta  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
Nervousperipherous   
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousoptic nerve
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • putative DNA binding domain
  • multimerization domain
  • HOMOLOGY
    interspecies homolog to murine Satb1
    Homologene
    FAMILY
  • cuticular collagen family
  • BANP/SMAR1 family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • modulaing chromatin and acting as negative regulators of the TCRbeta enhancer
  • tumor suppressor protein can modulate NF-KB transactivation and inhibit tumorigenesis by regulating NF-KB target genes (Singh 2009)
  • CELLULAR PROCESS nucleotide, replication
    nucleotide, repair
    nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • BTG3
  • interacting with histone deacetylation complex 1, SIN3, and pocket retinoblastomas to form a multiprotein repressor complex
  • may also interact with a specific nuclear matrix/scaffold-associated region (MAR)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in high grade breast cancer consequently enhancing the tumor-promoting functions of NF-KB (Singh 2009)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS