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FLASH GENE
Symbol CNTN6 contributors: mct/npt - updated : 27-09-2022
HGNC name contactin 6
HGNC id 2176
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
23 - 4074 114 1028 - 1998 9486763
25 - 4422 - 1028 - 1998 9486763
24 - 4185 - 1028 - 1998 9486763
24 - 4180 - 654 - 1998 9486763
22 - 3971 - 654 - 1998 9486763
24 - 4172 - 1028 - 1998 9486763
21 - 3916 - 843 - 1998 9486763
25 - 4413 - 1028 - 1998 9486763
24 - 4234 - 1028 - 1998 9486763
24 - 4176 - 1028 - 1998 9486763
23 - 4065 - 1028 - 1998 9486763
24 - 3957 - 992 - 1998 9486763
21 - 3758 - 654 - 1998 9486763
21 - 3753 - 924 - 1998 9486763
22 - 3928 - 956 - 1998 9486763
21 - 3743 - 654 - 1998 9486763
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineadrenal gland    
Hearing/Equilibriumear    
Nervousbrainhindbraincerebellum  
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • six Ig-like and four FNIII-like extracellular domains
  • a single transmembrane segment
  • a short cytoplasmic tail
  • HOMOLOGY
    Homologene
    FAMILY
  • immunoglobulin superfamily
  • F3/contactin family
  • CATEGORY adhesion
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • axonal guidance during development maintenance of synaptic connections in adult
  • glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule
  • triggering nuclear translocation of the Notch intracellular domain and promoting oligodendrogliogenesis from progenitor cells and differentiation of oligodendrocyte precursor cells via DTX1
  • CNTN4, CNTN5, CNTN6 play likely roles in brain development in a critical phase of establishing brain systems and their plasticity
  • serves likely developmental functions involving cell survival, migration and fasciculation
  • CNTN6 can modulate the activity of ADGRL1 by direct binding and suggests that CNTN6 may prevent apoptosis thereby impinging on neurodevelopment
  • role of protein-protein interactions in the potential mechanism of action of CNTN4, -5 and -6 , suggesting that complexes with other membrane proteins may play a role in neuronal developmental functions
  • CNTN6 plays likely a role in the development of hippocampus
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    CNTN6/Notch1 pathway via DTX1 promotes neural progenitor cell differentiation into oligodendrocytes
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with PTPRG (Abdelhakim 2010)
  • ADGRL1 is a binding partner for CNTN6 forming together a heteromeric cis-complex
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to abnormal auditory sensory perception in autism spectrum disorders
    Variant & Polymorphism other
  • CNTN6 mutations are risk factors for abnormal auditory sensory perception in autism spectrum disorders
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    Cntn6 is expressed in the developing hippocampus, and its deficiency in mice affects spatial learning and memory