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FLASH GENE
Symbol OGN contributors: mct - updated : 27-01-2014
HGNC name osteoglycin (osteoinductive factor, mimecan)
HGNC id 8126
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 splicing 2786 - 298 - Madisen, Mehrle
- splicing 2793 - 316 - Madisen, Mehrle
7 - 3068 - 298 - Madisen, Mehrle
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularvesselaorta  highly Mus musculus
Endocrineneuroendocrinepituitary    Homo sapiens
 parathyroid    
Hearing/Equilibriumearinnercochlea highly Mus musculus
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
cells
SystemCellPubmedSpeciesStageRna symbol
Hearing / Equilibriumcochlea cell Mus musculus
not specificchondrocyte Mus musculus
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
four leucine-rich repeats flanked by cysteine-rich regions
HOMOLOGY
interspecies homolog to murine Ogn
Homologene
FAMILY small leucine-rich proteoglycan family,class III
CATEGORY signaling growth factor
SUBCELLULAR LOCALIZATION extracellular
    intracellular
intracellular,cytoplasm,organelle,lumen
intracellular,cytoplasm,organelle,Golgi
intracellular,cytoplasm,organelle,lysosome
text extracellular matrix
basic FUNCTION
  • inducing bone formation in conjunction with transforming growth factor beta (TGFB1, TGFB2)
  • pituitary secretory protein, playing an important role in the regulation of cellular growth
  • may be modifiing the hypertrophic response to extrinsic factors such as hypertension and aortic stenosis
  • its downregulation is a fundamental requirement for proper arteriogenesis
  • important regulator of left ventricular mass through modulation of the TGF-beta pathway
  • DSPP, MEPE, VCAN, OGN play complementary roles during odontogenesis
  • may be a crucial humoral bone anabolic factor that is produced by muscle tissues
  • may be an important factor produced by muscle-derived cells and secreted into blood that exhibits bone anabolic effects
  • might play an important role in bone formation by osteoblasts at the well differentiated stage
  • CELLULAR PROCESS protein
    PHYSIOLOGICAL PROCESS development
    text bone formation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • OGN expressed in pituitary corticotroph cells mainly regulates ACTH secretion in the pituitary and coordinates the hypothalamo-pituitary-adrenal axis (HPAA)
  • cell & other
    REGULATION
    Other regulated by pituitary transcription factor-1 (POU1F1) as a marker for diagnosing pituitary tumors
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    its overexpression antagonized BMP2-induced differentiation of myoblastic cells into osteoblasts
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Ogn-deficient mice, have normal hearing thresholds