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FLASH GENE
Symbol KPNA4 contributors: mct - updated : 23-10-2018
HGNC name karyopherin alpha 4 (importin alpha 3)
HGNC id 6397
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
17 - 8981 57.8 521 - Ewing (2007)
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon  
Endocrinepancreas    
Lymphoid/Immunethymus    
Reproductivefemale systembreastmammary gland highly
 male systemtestis   
Respiratoryrespiratory tractlarynx  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
Epithelialsecretoryglandularexocrine 
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal importin beta-binding (IBB) domain
  • eight armadillo repeats and nuclear localization signal (NLS)
  • a C terminal acidic region
  • HOMOLOGY
    interspecies ortholog to murine Kpna4
    intraspecies homolog to KPNA2
    Homologene
    FAMILY importin alpha protein family
    CATEGORY signaling , receptor nuclear
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    intracellular,nuclear envelope
    basic FUNCTION
  • promoting docking of import substrates to the nuclear pore complex
  • mediating nuclear import of DHX9 through importin-alpha3/importin-beta-dependent pathway
  • KPNA4 is an HIV integrase-interacting cofactor that is required for efficient HIV-1 nuclear import and replication in both dividing and nondividing cells
  • unconventional nuclear localization signals (NLS) within nucleoprotein (NP) might have the additional ability to regulate the viral replication that is independent of nuclear localization activity via interactions with KPNA4
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • component of the NLS import receptor including an heterodimer of importin alpha and beta
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding the nuclear localization signal NLS of nuclear proteins
  • interacting with DHX9 (basic residues in RHA-NLS were used for interaction with importin-alpha)
  • nuclear localization of DAXX is controlled by two independent signals and KPNA4 through its NLS1 and NLS2 sequences
  • stress-induced accumulation of non-ubiquitinated TP53 in the cytoplasm promotes interaction with KCNA4 and rapid import
  • KPNA3 and KPNA4 are key binding partners of MECP2, and mediate the nuclear import of MECP2
  • KPNA4 mediates the cytoplasm-to-nucleus translocation of transcription factors, including nuclear factor kappa B
  • KPNA4 is an important regulator of CNTF-induced oligodendrocyte differentiation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • KPNA4 is a potential novel biomarker for Prostate carcinoma metastasis
  • Therapy target
    ANIMAL & CELL MODELS