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FLASH GENE
Symbol BCL6B contributors: mct - updated : 25-01-2014
HGNC name B-cell CLL/lymphoma 6, member B (zinc finger protein)
HGNC id 1002
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 3544 51.6 480 - Sakashita (2002)
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Respiratoryrespiratory tracttrachea  highly
cell lineage immature B cell lineage
cell lines erythroleukemia cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • BTB/POZ domain
  • five repeats of the Krüppel-like zinc finger motif at the N and C terminus
  • conjugated MetalloP
    HOMOLOGY
    interspecies homolog to murine Bcl6b
    intraspecies homolog to BCL6
    Homologene
    FAMILY BTB/POZ family
    CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • repressor, having protein binding activity
  • regulating differentiation in stages or lineages different from those regulated by BCL6
  • required for the enhanced magnitude of the secondary response of memory CD8(+) T cells
  • BCL6 and BCL6B regulate hematopoietic progenitor cells (HPC) homeostasis by an indirect pathway involving CD8 T cell
  • mediates KDR and Notch cross-signaling in angiogenesis
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    Zn2+
    protein
  • FGF2 depends on MAP2K1 signaling to drive spermatogonial stem cell (SSC) self-renewal via upregulation of the ETV5 and BCL6B genes
  • PRKD2, mediated BCL6B gene expression by VEGFA stimulation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • BCL6B methylation may serve as a novel potential non-invasive plasma biomarker for the detection of gastric cancer
  • Therapy target
    ANIMAL & CELL MODELS