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FLASH GENE
Symbol GGA2 contributors: mct/npt - updated : 19-04-2015
HGNC name golgi associated, gamma adaptin ear containing, ARF binding protein 2
HGNC id 16064
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 5078 - 223 - Hirst (2007)
an additional exon between exons 6 and 7, lacking downstream sequence
17 - 5973 67.2 613 - Hirst, Wang (2007)
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumcardiac  
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
muscularslow twitch
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES globular
STRUCTURE
motifs/domains
  • VHS domain at N terminus
  • a typical ear domain at C terminus
  • GAT domain
  • HOMOLOGY
    Homologene
    FAMILY
  • ADP-ribosylation factor binding protein family
  • GGA protein family
  • CATEGORY adaptor , transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    basic FUNCTION
  • involved in vesicle transport through trans-Golgi (facilitation of the trafficking of proteins between trans-Golgi network and lysosome)
  • sorting MGP receptors and lysosome enzymes
  • implicated in the sorting of mannose 6-phosphate receptor (MPR) (Hida 2007)
  • recruited to the TGN independently of the other GGAs and required for the efficient sorting of lysosomal enzymes (Hida 2007)
  • monomeric clathrin adaptors that mediate cargo sorting and vesicle formation at the TGN (Del Castillo 2010)
  • conserved role for GGA1, GGA2, GGA3 proteins in regulating phosphatidylinositol 4-kinase function at the TGN
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS exocytosis transport , cellular trafficking transport
    text heterotopic vesicle/suborganelle interactions associated with the Gogi complex
    PATHWAY
    metabolism
    signaling
    a component
  • complexing through the VHS domain with the cytoplasmic domains of sorting receptors such as the mannose phosphate receptor by recognizing the acidic cluster dileucine (ACLL) sequences
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting by its VHS domain with the cytoplasmic tail of sortilin SORT1
  • binding BACE
  • interaction between GGA1, GGA2, GGA3 and RABEP1 is likely to take place in a pathway between the trans-Golgi network and early endosomes
  • bind PI4P primarily through their GAT domain, in a region called C-GAT that also binds ubiquitin (Wang 2007)
  • associated with Golgi membranes through interaction between their GGAH domains and ADP-ribosylation factors
  • interacting with CNST (Del Castillo 2010)
  • MON2 directly interacts with GGA1, GGA2, GGA3 through the VHS domain
  • PI4KB interacted preferentially with the VHS domain of GGA2 compared with VHS domains of GGA1 and GGA3
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS