Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol PCOLCE2 contributors: KTN/npt - updated : 30-01-2009
HGNC name procollagen C-endopeptidase enhancer 2
HGNC id 8739
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 1988 45.6 415 - -
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Endocrineneuroendocrinepituitary  highly
 pancreas    
Nervousbrain   lowly
Reproductivefemale systembreastmammary gland highly
 female systemplacenta  highly
Respiratorylung    
 respiratory tracttrachea  highly
Urinarybladder   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivecartilage   
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo, fetal, pregnancy
Text placenta highly, eye trabecular meshwork
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
  • an N-terminal signal sequence of 23 aa
  • two CUB domains at the N terminus
  • an NTR domain at the C terminus
  • a putative myristoylation site
  • several potential phosphorylation sites
  • a putative glycosylation site
  • an RGD site
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine Pcolce2 (87.4 pc)
    intraspecies homolog to PCOLCE
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    basic FUNCTION
  • enhancing cleavage of type I procollagen C-propeptide by BMP1 (Steiglitz 2002)
  • activating BMP1
  • CELLULAR PROCESS protein, post translation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism aminoacid
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to the COOH-terminal propeptide of type I procollagen (Steiglitz 2002)
  • interacting with heparin with high affinity and type II collagen (Steiglitz 2002)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • for GLC1C (Xu 2000)
  • Marker
    Therapy target
    ANIMAL & CELL MODELS