basic FUNCTION
| catalyzing the cis-trans isomerization of proline imidic peptide bonds in oligopeptides |
|
accelerate the folding of proteins |
|
PPIF-dependent mitochondrial permeability transition (mPT), regulates some forms of necrotic death, but not apoptotic death |
|
mitochondrial immunophilin and a key positive regulator of the mitochondrial permeability transition (MPT) |
|
physiologic function for PPIF and the mitochondrial permeability transition (MPT) in the regulation of starvation-induced autophagy |
|
mitochondrial matrix peptidyl-prolyl isomerase known to modulate opening of the mitochondrial permeability transition pore (MPTP) |
|
coronavirus-induced neuronal programmed cell death is PPIF dependent and potentially caspase dispensable |
|
mitochondrial matrix peptidyl prolyl isomerase and apoptosis regulator |
|
directs mitochondria-to-nuclei inflammatory gene expression in normal and tumor cells |
|
role for PPIF in modulating protein acetylation |
|
activation of PPIF-mediated MPTP opening is associated with the apoptotic pathway and the mitochondrial alteration in retinal ganglion cell death of ischemic retinal injury |
|
mitochondrial thioredoxin system controls the redox state of PPIF which, in turn, may act as a regulator of several processes including ROS production and pro-apoptotic factors release |
|
regulates mitochondrial metabolism, and likely cell survival, by promoting more efficient electrons flow through the respiratory chain via increased supercomplex formation |
|
not only regulates the permeability transition pore (PTP), but also regulates the dynamics of synthasome assembly depending on the bioenergetic state of the mitochondria |
|
controls the opening of mitochondrial permeability transition por |
|
physiological function of PPIF in dendritic plasticity by acting as a fine-tuner of mitochondrial calcium homeostasis |
|
is involved in the regulation of inflammation in aorta |
|
mitochondrial PPIF is involved in the inhibitory effect of high-fat diet (HFD) on STAR expression in testes |
|
is an important contributor to Pb-induced mitochondrial abnormality |