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FLASH GENE
Symbol PDC contributors: mct - updated : 10-12-2014
HGNC name phosducin
HGNC id 8759
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- splicing 1258 28.2 246 - Nishigushi
- splicing 1221 - 194 - Nishigushi
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinepineal    
Visualeyeretina  predominantly Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsensoryvisual  
cells
SystemCellPubmedSpeciesStageRna symbol
Visualcone photoreceptor Homo sapiens
Visualrod photoreceptor Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a phosducin domain
  • HOMOLOGY
    interspecies ortholog to murine Pdc (86 pc)
    Homologene
    FAMILY phosducin family
    CATEGORY signaling , receptor membrane G
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • (transducin) inhibitor protein, participating in the regulation of visual phototransduction or in the integration of photoreceptor metabolism
  • previously unrecognized target of SUMO modification and SUMOylation controls phosducin stability in cells as well as its functional properties
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction , sensory transduction/vision
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other regulated at the posttranslational level by modification with the small ubiquitin-related modifier, SUMO
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS