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FLASH GENE

Symbol

DMGDH

contributors: mct - updated : 07-04-2020

HGNC name	dimethylglycine dehydrogenase
HGNC id	24475

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_013391 16 - 3173 NP_037523 - 866 - 2015 25795213

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver         Urinary kidney

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	43AA leader peptide, N terminus
	FAD dependent oxidoreductase
	folate-binding domain
	a C-terminal barrel domain

mono polymer

monomer

HOMOLOGY

interspecies

ortholog to rattus Dmgdh (86 pc)

intraspecies

homolog to SARDH

Homologene

FAMILY	Thi4 family
	gcvT (Glycine cleavage T protein, aminomethyl transferase) family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria,matrix

basic FUNCTION	catalyzing the oxidative demethylation of dimethylglycine to form sarcosine
	playing a role in choline catabolism in the liver
	mitochondrial enzyme that catalyzes the oxidative demethylation of dimethylglycine to sarcosine
	plays a prominent role in choline and 1-carbon metabolism
	mitochondrial enzyme which plays an important role in the utilization of methyl groups derived from choline
	is a flavin adenine dinucleotide (FAD)- and tetrahydrofolate (THF)-dependent, mitochondrial matrix enzyme taking part in choline degradation, one-carbon metabolism and electron transfer to the respiratory chain

CELLULAR PROCESS

protein, degradation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

aminoacid

signaling

a component

INTERACTION

DNA

RNA

small molecule	cofactor,
	requires flavin adenine dinucleotide (FAD)

protein

its expression suppresses metastasis through the AKT1 signaling pathway

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

DMGDHD

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in hepatocellular carcinoma constitutional       loss of function in diabetes development

Susceptibility

Variant & Polymorphism

Candidate gene	candidate gene for non-syndromic cleft lip with or without cleft palate (NSCL/P
Marker	is a potential valuable biomarker for both diagnosis and prognosis for HCC (hepatocellular carcinoma)
Therapy target

ANIMAL & CELL MODELS