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FLASH GENE
Symbol IL36RN contributors: mct - updated : 26 -08 -20
HGNC name interleukin 36 receptor antagonist
HGNC id 15561
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
STRUCTURE 6.00 kb     5 Exon(s)
text structure two alternative non coding first exons
MAPPING cloned Y linked N status confirmed
Map cen - IL1A - IL1B - IL1F7 - IL1F9 - IL1RN - IL1F5 - qter
Authors Busfield (00)
regionally located cluster of IL1related genes
RNA
TRANSCRIPTS type messenger
text two alternative non coding first exons
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 initiation site 2717 17 155 - 2000 10744718
5 - 2689 - 155 - 2000 10744718
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus     Homo sapiens
Respiratoryrespiratory tracttrachea    Homo sapiens
Skin/Tegumentskin   highly Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier/lining   
Lymphoid    
Nervouscentral   
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
Digestiveepithelial cell Homo sapiens
Lymphoid/Immunemacrophage
Skin/Tegumentkeratinocyte
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • twelve stranded beta-trefoil structure
  • has the same beta-trefoil fold as other IL1 family members, and the hydrophobic core is well conserved, but there are substantial differences in the loop conformations
  • conjugated GlycoP , Other
    HOMOLOGY
    interspecies ortholog to murine Il1f5
    Homologene
    FAMILY interleukin 1 cytokine family
    CATEGORY secretory , signaling cytokine
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • putative antagonist of IL1 receptor
  • involved in innate immune responses to infection and injury
  • mediates anti-inflammatory effects through its ability to induce IL4 production and this is a consequence of its interaction with the orphan receptor, single Ig IL-1R-related molecule (SIGIRR)/TIR8
  • primary inflammatory cytokine, that may play an important role in the susceptibility to developing rheumatoid arthritis
  • IL1 family receptor antagonist, which opposes the activity of the IL36A and IL36G innate cytokines
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense , inflammation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • activating NF-kappa B through the IL1 receptor
  • bind to specific receptors and cause activation of NFkappaB and MAP kinase
  • cell & other
    REGULATION
    induced by phorbol ester (PHA) and lipopolysaccharide (LPS)
    ASSOCIATED DISORDERS
    corresponding disease(s) GPP
    Susceptibility
  • .to common forms of psoriasis
  • Variant & Polymorphism other putative dysregulation of the interleukin-36–interleukin-36Ra signaling pathway may confer a predisposition to common forms of psoriasis
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS