SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
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| intracellular,cytoplasm,organelle,mitochondria,matrix
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| intracellular,cytoplasm,organelle,lumen
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
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| type II integral membrane protein |
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ERO1alpha is almost exclusively found on the mitochondria-associated membrane (MAM), and the localization of ERO1A on the MAM is dependent on oxidizing conditions within the ER |
basic FUNCTION
| essential oxidoreductase that oxidizes proteins in the endoplasmic reticulum to produce disulfide bonds |
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may be responsible for a significant proportion of reactive oxygen species (ROS) in the cell, thereby being a source of oxidative stress |
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combined activities of ERO1L and protein disulphide isomerase are necessary for formation of disulphide bonds within the mammalian endoplasmic reticulum (ER) (Baker 2008) |
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hypoxic induction of ERO1L is the key adaptive response in a previously unrecognized HIF-1-mediated pathway that operates to improve protein secretion under hypoxia and might be harnessed for inhibiting tumor growth via inhibiting VEGF-driven angiogenesis (May 2005) |
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catalyzes the formation of disulfide bond and hence plays an essential role in protein folding (Chu 2009) |
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key controller of oxidative folding and ER redox homeostasis, enriched in mitochondrial-associated ER membranes (MAM) and regulating Ca(2+) fluxes |
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levels, subcellular localization, and activity of ERO1A coordinately regulate Ca(2+) and redox homeostasis and signaling in the early secretory compartment |
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ERP44 together with ERO1A plays an important role in disulfide formation of SLC6A4, which may be a prerequisite step for the assembly of SLC6A4 molecules in oligomeric form |
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ERO1A hyperactivity affects cell viability when cellular glutathione levels are compromised |
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different binding properties of ERO1A and PRDX4 increase the robustness of ER redox homeostasis |
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oxidizing enzyme that exists in the endoplasmic reticulum and is induced under hypoxia |
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cancer-associated ERO1A regulates the expression of the MHC class I molecule via oxidative folding |