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FLASH GENE
Symbol TAF1A contributors: mct - updated : 17-06-2020
HGNC name TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa
HGNC id 11532
DNA
TYPE functioning gene
STRUCTURE 32.19 kb     10 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 splicing 1910 - 450 - 2001 11250901
11 splicing 1796 - 336 - 2001 11250901
12 - 1966 - 450 - 2001 11250901
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouthtongue   
 stomach    
Lymphoid/Immunelymph node    
Nervousbrain    
Reproductivefemale systemuteruscervix  
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text fetal tissues
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Taf1a
Homologene
FAMILY
CATEGORY DNA associated , transcription factor
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,cytoskeleton,microtubule
intracellular,nucleus,nucleoplasm
basic FUNCTION
  • involved in the initiation of transcription by RNA polymerase 2
  • initiation of transcription for ribosomal RNA (rRNA) by RNA polymerase I requires TBP and TBP-associated factors (TAF1A, TAF1B and TAF1C)
  • TAF1A functions in recruitment of RNA polymerase I to ribosomal DNA promoters, the essential first step in ribosome biogenesis
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component of SL1 (complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I), general transcription factor associated with POLR1, synthesis of 45S RNA precursors
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with helix 2 of TBP
  • TBP loading by AFF1 through TAF1A, TAF1B, TAF1C is the major rate-limiting step in MLL fusion-dependent transcription
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CMDTAF1AD
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS