basic FUNCTION
| coordinated assembly of focal adhesions and stress fibers |
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linking growth factor receptors to the activation of actin polymerization |
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playing a critical role in muscle differentiation |
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involved in endosome dynamics |
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may coordinate membrane transport with the function of the cytoskeleton |
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RHOD-kinase dependent cell contractility contributes to global and local matrix remodeling, whereas RHOD dependent activation of DIAPH1 and/or other downstream effectors regulates the structure and number of cell processes |
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mediates various phenotypes of malignant transformation by RAS and SRC through its effectors, ROCK1 and DIAPH1 |
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its activation is required to stabilize midzone microtubules, and to maintain the midzone structures after anaphase onset or during cytokinesis |
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participating in reorganization of actin cytoskeleton |
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is involved in the regulation of G1/S-phase progression and causes overduplication of centrosomes |
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RHOD participates in the regulation of cell-cycle progression and centrosome duplication |
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regulates actin cytoskeleton to collapse actin stress fibers and focal adhesions |
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coordinates Arp2/3-dependent and FLNA-dependent mechanisms to control the actin filament system, cell adhesion, and cell migration |
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coordinates actin dynamics and membrane trafficking |
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has a regulatory role in endosome trafficking |
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is a Golgi component with a role in anterograde protein transport from the ER to the plasma membrane |
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actin cytoskeleton is dynamically regulated by increased or decreased protein levels of RHOD |
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RHOD is an important component in the control of actin dynamics and directed cell migration |
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have a major impact on the organization and function of the actin filament system |
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has an elevated intrinsic GDP/GTP exchange activity, rendering the protein constitutively active |