basic FUNCTION
| functioning as an effector or regulator of RAS |
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regulates endocytosis of the EPHA4 receptor in mature excitatory neurons (Deininger 2008) |
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play an important role in the endocytosis of the epidermal growth factor receptor (EGFR) |
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regulates EGFR degradation in cooperation with STAM, defining a novel role for Rin1 in regulating endosomal trafficking |
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serves as an important signal transduction system for evaluating the malignancy of colorectal cancer |
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RAS effector regulating epithelial cell properties |
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acting as a negative regulator of tumor cell invasive growth and that this requires the ABL kinase-signaling function of RIN1, suggesting a mechanism through which RIN1 silencing may contribute to breast cancer progression |
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selective association of RAB5A and RIN1 contributes to the dominance of RAB5A in EGFR trafficking, whereas RAB5B, RAB5C may have major functions unrelated to the EGFR degradation pathway |
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RAS effector protein involved in the regulation of epithelial cell processes such as cell migration and endocytosis |
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growth factor-directed cell migration, a physiological process that involves receptor endocytosis and actin remodeling, also requires the ability of RIN1 to coordinate RAB5 GTPase and ABL tyrosine kinase pathways |
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is a host cell regulator that performs counterbalancing functions during early and late stages of L. monocytogenes infection |