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FLASH GENE
Symbol KLF12 contributors: - updated : 08-06-2005
HGNC name Kruppel-like factor 12
HGNC id 6346
DNA
TYPE functioning gene
STRUCTURE 321.00 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 10891 44.3 4029 - Imhof
- splicing 1597 29.6 269 - -
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunelymph node   highly
 spleen   highly
Nervousbrain    
Urinarykidney    
Visualeye    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three Gli-Krüppel C2H2 type zinc finger at the C terminus
  • a highly conserved 81 AA DNA binding domain
  • a H/C knuckle, a serine/threonine rich domain
  • a PVDLS motif contacting C terminal binding proteins
  • conjugated PhosphoP
    HOMOLOGY
    Homologene
    FAMILY CACCC binding zinc finger family,C2H2 type zinc finger protein
    CATEGORY transcription factor , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION transcriptional silencer to the AP2-alpha gene, mediating positive and negative regulation of the AP2-A expression trhough a set of overlapping cis-regulatory promoters elements
    CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    text regulation of development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA bindingto O-regulatory element (A32) in the AP-2 alpha gene promoter
    RNA
    small molecule metal binding,
    zinc Zn2+
    protein interacting with CTBP1 for corepression of AP2A1 complex
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS