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FLASH GENE
Symbol SCARF1 contributors: mct - updated : 26-10-2010
HGNC name scavenger receptor class F, member 1
HGNC id 16820
DNA
TYPE functioning gene
STRUCTURE 11.89 kb     11 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 splicing 3457 87.4 830 - 2002 11978792
also called SREC
11 splicing 3420 60.8 569 - 2002 11978792
9 splicing 3185 78.7 744 - 2002 11978792
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  highly
Endocrinethyroid   highly
Hearing/Equilibriumear   highly
Lymphoid/Immunespleen   highly
Respiratorylung    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier/lining   
cells
SystemCellPubmedSpeciesStageRna symbol
Cardiovascularendothelial cell
cell lineage
cell lines
fluid/secretion
at STAGE
Text
  • differentially expressed during epidermal differentiation
  • PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • six EGF-like domains
  • an extremely large cytoplasmic domain
  • ten repeats of epidermal growth factor-like cysteine-rich motifs in the extracellular domains
  • unusually long C-terminal cytoplasmic domains with Ser/Pro-rich regions
  • four conserved EF-hand motifs (predicted to be Ca2+-binding domains)
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Scarf1
    intraspecies homolog to SCARF2 (highly)
    Homologene
    FAMILY
  • scavenger receptor type F family
  • CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type I membrane protein
    basic FUNCTION
  • playing a role in the binding and degradation of acetylated low density lipoprotein
  • receptor mediated endocytosis
  • mediates the endocytosis of calreticulin and HSP90B1
  • having ability to internalize modified low-density lipoprotein (LDL), such as acetylated and oxidized LDLs
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS cell to cell transport , endocytosis transport
    text intercellular transport
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    acetylated low density lipoprotein
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to acetylated low density lipoprotein
  • heterophilic interaction between SCARF1 and SCARF2 at their extracellular domains
  • interacting with AVIL (co-expressed and interacted with each other in dorsal root ganglion neurons during embryonic development, and involved in the development of dorsal root ganglion neurons by inducing the described morphological changes)
  • with SCARB1 and MSR1, are receptors for UMOD
  • SCARF1 and SCARF2, show weak cell-cell interaction by their extracellular domains (termed homophilic trans-interaction) but display strong heterophilic trans-interaction through the extracellular epidermal growth factor-like repeat domains
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to atherosclerosis
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS