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FLASH GENE
Symbol NCKAP1 contributors: mct - updated : 18-11-2020
HGNC name NCK-associated protein 1
HGNC id 7666
DNA
TYPE functioning gene
STRUCTURE 129.34 kb     32 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
32 - 20350 - 1134 - 2019 30867003
31 - 20332 - 1128 - 2019 30867003
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Nervousbrain   highly Homo sapiensAdult
 brain   highly Homo sapiensFetal
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumcardiac  
Muscularstriatumskeletal  
Nervousperipherous   
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a large transmembrane segment
  • HOMOLOGY
    interspecies ortholog to rattus Nap1
    Homologene
    FAMILY
  • HEM-1/HEM-2 family (tyrosine kinase binding protein)
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text
  • putative type II membrane protein
  • located at both nucleus and cytoplasm
  • basic FUNCTION
  • potentially involved in apoptosis of neuronal cells
  • NCKAP1 inhibit likely cells from entering G2/M phase
  • regulates neuronal cytoskeletal dynamics and is essential for neuronal differentiation in the developing brain
  • might have a cell-type-specific function in the development of neocortex
  • is likely essential for neuronal mechanical changes in the cytoskeleton, which are essential for accurate timing during post-migratory differentiation
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • protein constituent of membrane
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NCK associated
  • NCKAP1 is a cell invasion promoter by binding to WASF1, but also a tumor suppress gene that modulates the cell cycle of hepatocellular carcinoma (HCC) cell lines by targeting RB1/TP53 regulation
  • NCKAP1 interacts directly with CYFIP2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) NDDAID
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in sporadic Alzheimer's disease
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    loss of Nckap1 in mice leads to neural tube and neuronal differentiation and migration defects in mouse developing brain