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FLASH GENE
Symbol SNX5 contributors: mct/npt - updated : 17-05-2008
HGNC name sorting nexin 5
HGNC id 14969
DNA
TYPE functioning gene
STRUCTURE 27.00 kb     13 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
text alternative spliced transcripts 1 and 2 encode the same protein
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
14 - 2154 46.8 404 - Wassmer (2007)
13 - 2058 46.8 404 - Wassmer (2007)
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineadrenal gland   highly
 parathyroid   highly
Lymphoid/Immunelymph node   highly
Reproductivefemale systemplacenta  highly
cell lineage
cell lines cancer cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES Hydrophilic
STRUCTURE
motifs/domains
  • a phosphoinositide-binding Phox homology (PX) domain, characteristic of SNX family
  • HOMOLOGY
    Homologene
    FAMILY
  • sorting nexin family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    text
  • colocalised with SNX1 and SNX6 on early endosomes
  • colocalized with DOCK1 at endosomes
  • basic FUNCTION
  • involved in receptor trafficking between organelles
  • may have functions not only associated with endosomal sorting but also with the phosphoinositide-signaling pathway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text receptor trafficking
    PATHWAY
    metabolism
    signaling
    phosphoinositide-signaling pathway
    a component
  • components of the mammalian retromer (a multimeric protein complex involved in mediating endosome-to-trans-Golgi-network retrograde transport of the cation-independent mannose-6-phosphate receptor)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • FANCA binding
  • receptor tyrosine kinases
  • VIMP can interact with CKAP4 and SNX5, it does not interact with MT-binding ER proteins (such as REEP1) that shape the tubular smooth ER
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS