basic FUNCTION
| adhesion molecule active in neural crest cells during embryonic development |
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play an important role in developing and malignant progression of prostate cancer |
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may play a role in uveal melanoma growth (Lai 2007) |
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plays a critical role in cell proliferation and activation, and contributes to inflammatory reactions (Wang 2008) |
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might be a novel marker for renal tubular epithelial cells, correlating with cell proliferation and cell-cell conjunctions (Wang 2008) |
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endothelial cell adhesion molecule, implicated in blood vessel formation (Zheng 2009) |
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required for the activation of MAPK14/IKK/NF kappaB signaling cascade and up-regulation of NF kappaB downstream pro-angiogenic genes (Zheng 2009) |
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might serve as not just a cell adhesion molecule but also a membrane signal receptor in tumor-induced angiogenesis (Zheng 2009) |
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its expression differentiates between perivascular versus endosteal localization of non-hematopoietic bone marrow mesenchymal stem cells (BM-MSCs) population |
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is a unique activator of epithelial-mesenchymal transition (EMTs) and significantly correlates with triple-negative breast cancer |
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is highly specific for myogenic progenitor cells only in primary tissue |
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its expression strongly correlates with myogenic activity in human fetal muscle |
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is a new coreceptor for KDR and is therefore a promising target for blocking tumor-related angiogenesis |
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actively involved in miscellaneous processes, such as development, signaling transduction, cell migration, mesenchymal stem cells differentiation, angiogenesis and immune response |
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endothelial MCAM plays an active role in the CNS-directed extravasation of encephalitogenic T cells |
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involved in cell-cell cohesion and permeability (Bardin 2009) |
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adhesion molecule localized at endothelial cell junctions and facilitates cell-cell interactions |
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inhibits canonical Wnt signalling by promoting CTNNB1 degradation |