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FLASH GENE
Symbol STK24 contributors: mct/npt/pgu - updated : 12-06-2010
HGNC name serine/threonine kinase 24 (STE20 homolog, yeast)
HGNC id 11403
DNA
TYPE functioning gene
STRUCTURE 126.94 kb     11 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Map cen - D13S159 - STK24 - D13S1267 - PCCA PCCA - D13S174 - D13S158 - D13S280 - qter
Authors Gene Map
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 4624 - 431 - 2010 19782762
11 - 4539 - 443 - 2010 19782762
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Endocrinepancreas    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
life cycle quiescence
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal kinase domain
  • a regulatory domain at its C-terminus
  • HOMOLOGY
    interspecies homolog to yeast SpS1/Ste20 yeast
    Homologene
    FAMILY
  • germinal center kinase-III family
  • protein kinase superfamily
  • STE Ser/Thr protein kinase family
  • STE20 subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • its caspase-mediated proteolytic activation contributes to apoptosis
  • essential role in the oxidative stress-induced apoptosis of trophoblasts of term placenta in normal spontaneous delivery
  • regulates axon regeneration in both CNS and PNS neurons
  • mediates oxidative-stress-induced cell death by modulating JNK activation
  • mediates the axon-promoting effects of trophic factors in mature rat retinal ganglion cells (RGCs) and dorsal root ganglion (DRG) neurons, and is essential for axon regeneration
  • may respond to staurosporine to trigger the caspase-independent apoptotic pathway by regulating the nuclear translocation of apoptosis-inducing factor and endonuclease G, and the nuclease activity associated with endonuclease G
  • is up-regulated and plays an important role in hypoxia-induced apoptosis of trophoblasts
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • PDCD10 can heterodimerize with GCKIII kinases (STK24, MST4, and STK25) to regulate cardiovascular development
  • STK24-STK38/STK38L-CDKN1A axis is an important regulator of G(1)/S progression of mammalian cells
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • STK24-STK38-CDKN1A axis is an important regulator of G(1)/S progression of mammalian cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS