basic FUNCTION
| its caspase-mediated proteolytic activation contributes to apoptosis |
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essential role in the oxidative stress-induced apoptosis of trophoblasts of term placenta in normal spontaneous delivery |
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regulates axon regeneration in both CNS and PNS neurons |
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mediates oxidative-stress-induced cell death by modulating JNK activation |
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mediates the axon-promoting effects of trophic factors in mature rat retinal ganglion cells (RGCs) and dorsal root ganglion (DRG) neurons, and is essential for axon regeneration |
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may respond to staurosporine to trigger the caspase-independent apoptotic pathway by regulating the nuclear translocation of apoptosis-inducing factor and endonuclease G, and the nuclease activity associated with endonuclease G |
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is up-regulated and plays an important role in hypoxia-induced apoptosis of trophoblasts |