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FLASH GENE
Symbol CCT6A contributors: mct/npt/pgu - updated : 27-03-2013
HGNC name chaperonin containing TCP1, subunit 6A (zeta 1)
HGNC id 1620
DNA
TYPE functioning gene
STRUCTURE 12.31 kb     14 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
14 - 2682 - 531 - 2005 16236267
13 - 2547 - 486 - 2005 16236267
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivestomach   highly
Reproductivefemale systemuterus  highly
Skin/Tegumentskin   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
ATP-binding sites perfectly conserved among mammals and yeast
mono polymer heteromer
HOMOLOGY
interspecies homolog to yeast S.cerevisiae
Homologene
FAMILY
  • TCP-1 chaperonin family
  • TF55/TCP-1 family
  • CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • mediating ATP-dependent monomeric protein folding
  • molecular chaperone that assists the folding of proteins upon ATP hydrolysis
  • required for maturation of sphingosine kinase 1
  • CCT complex is responsible for the folding of a number of proteins including actin and tubulin
  • might play an essential role in modulation of folding of polyglutamine expanded proteins and could be another target for further therapeutic studies
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of a heterooligomeric complex, subunits of the CCT complex involved in ATP-dependent folding of cellular proteins
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with androgen receptor (AR)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS