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FLASH GENE
Symbol PARP4 contributors: - updated : 25-08-2005
HGNC name poly (ADP-ribose) polymerase family, member 4
HGNC id 271
DNA
TYPE functioning gene
STRUCTURE 91.00 kb     34 Exon(s)
MAPPING cloned Y linked   status confirmed
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen    
Cardiovascularheart    
Digestiveliver    
Endocrinepancreas    
Respiratorylung    
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Lymphoid    
Muscularstriatumcardiac  
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an uncleavable signal peptide,lacking the DNA-binding and the automodification domains, but retaining the catalytic domain
  • a transmembrane segment
  • a SH3 ligand binding motif (SH3) in the C terminal region
  • HOMOLOGY
    interspecies homolog to C.elegans poly ADP ribose synthase
    intraspecies homolog to ADPRT
    Homologene
    FAMILY inter-alpha-inhibitor pathway superfamily poly (ADP-ribase) polymerase (PARP) family
    CATEGORY enzyme , DNA associated , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,vault
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus,chromatin/chromosome
    CELLULAR PROCESS nucleotide, repair
    nucleotide, genomic integrity
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism drug
    signaling
    a component component of ribonucleoprotein vault complex, likely involved in DNA repair
    INTERACTION
    DNA
    RNA
    small molecule
    protein major vault protein (MVP)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS