Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

MYBBP1A

contributors: mct - updated : 24-01-2015

HGNC name	MYB binding protein (P160) 1a
HGNC id	7546

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	16.73 kb     27 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

confirmed

Map	pter - D17S34 - D17S849 - D17S695 - D17S926 - D17S5 - D17S379 - D17S1828 - [D17S861E - ALOX15 ] - D17S938 - cen
Authors	Keough (99)
Text	[MYBBP1A ]

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001105538 27 - 4122 NP_001099008 149.2 1332 - 1999 10644447 isoform 1 NM_014520 26 - 4585 NP_055335 148.7 1328 - 1999 10644447 isoform 2 a central acidic region C-terminal basic amino acid repeats a number of potential leucine charged domain motifs

EXPRESSION

Type	ubiquitous

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon     Endocrine pancreas         Lymphoid/Immune spleen       highly Nervous brain         Reproductive female system uterus cervix   moderately   male system prostate       Respiratory respiratory tract larynx     moderately Skin/Tegument skin       moderately Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine

cell lineage
cell lines
fluid/secretion	highly in lymph

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies	homolog to rattus Mybbp1a (69.9 pc)
	homolog to murine Mybbp1a (71.3 pc)

Homologene

FAMILY

CATEGORY

regulatory , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus,nucleoplasm
	intracellular,nucleus,nucleolus
text	predominantly nucleolar
	shuttling between the nucleus and cytoplasm
	nuclear import may be mediated by KPNA2, while export appears to depend partially on XPO1/CRM1
	when rRNA transcription was suppressed by nucleolar stress, MYBBP1A translocated to the nucleoplasm and facilitated TP53-EP300 interaction to enhance TP53 acetylation
	nucleolar stress induces translocation of the nucleolar protein MYBBP1A from the nucleolus to the nucleoplasm and enhances TP53 activity

basic FUNCTION	may activate or repress transcription via interactions with sequence specific DNA-binding proteins
	repressing JUN, MYB and PPARGC1A
	stimulating transcription by AHR
	may function to regulate cell type specific genes
	may connect the ribosome biogenesis and the Myb-dependent transcription, which controls cell cycle progression and proliferation
	novel substrate of AURKB and may be involved in mitosis (Perrera 2010)
	regulates levels and processing of pre-ribosomal RNA (
	co-repressor role of MYBBP1A in rRNA expression
	is an essential gene with novel roles at the pre-mitotic level and potential tumor suppressor activity
	plays catalytic roles in TP53 acetylation and activation
	nucleolar stress induces translocation of the nucleolar protein MYBBP1A from the nucleolus to the nucleoplasm and enhances TP53 activity
	likely plays a pivotal role in the cellular stress response

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

binding

RNA

small molecule

protein	binding to JUN and MYB via the leucine zipper regions present in these proteins
	binding to PPARGC1A
	binding to AHR
	binding to KPNA2
	is a novel substrate of VHL
	associated with both the RNA polymerase I complex and the ribosome biogenesis machinery
	specifically interacts with nonacetylated TP53 and induces TP53 acetylation
	MYBBP1A binds to SIRT7 and is a novel negative regulator of SIRT7
	functions to enhance TP53 tetramerization that is necessary for TP53 activation
	ANKH /MYBBP1A and SPHK1 interactions stimulate catabolic events in IL1B-mediated cartilage degradation
	interaction of MYBBP1A with CDK2 and TPP2, to form a protein-protein interaction network

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS