SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
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| intracellular,cytoplasm,cytosolic
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text
| like RNF123, is localized to the cytosol |
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tail-anchored ubiquitin-specific protease localized to the ER |
basic FUNCTION
| involved in the ubiquitin-dependent proteolytic pathway in conjunction with the 26S proteasome |
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deubiquitinating enzyme that regulates the stability of a cyclin-dependent kinase inhibitor and demonstrate that progression through G1 to S phase is, like the metaphase-anaphase transition, controlled in a hierarchical, multilayered fashion |
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rescues the ER-associated-degradation (ERAD) substrates CFTRDelta508 and TCR-alpha from proteasomal degradation |
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function on specific ERAD substrates |
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modulates transcription of major myofibrillar proteins and the ubiquitin system not only mediates the increased protein breakdown but is also involved in the decreased protein synthesis in atrophying skeletal muscle |
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positively regulates proliferation in fibroblasts by stabilizing RNF123, a ubiquitin ligase for CDKN1B |
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regulates hypoxia-inducible factor 1A (HIF1A) during hypoxia |
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only the ER-localized isoform of USP19 (USP19-ER) modulated myoblast fusion as well as the expression of myogenin and myofibrillar proteins, and these effects were also dependent on USP19 catalytic activity |
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USP19 is involved in human muscle wasting |
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possible function of USP19 in quality control of misfolded proteins by regulating their protein levels |
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USP19 is involved in the regulation of ERAD by controlling the stability of MARCHF6 via deubiquitination |
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dual functions of the USP19-BECN1 axis by balancing autophagy and the production of type IIFNs |
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USP19 is a key factor in modulating DNA damage repair by targeting HDAC1/2 K63-linked ubiquitination |
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USP19 is an important regulator of fat development |