Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol PLAA contributors: mct/npt - updated : 06-06-2017
HGNC name phospholipase A2-activating protein
HGNC id 9043
DNA
TYPE functioning gene
STRUCTURE 44.10 kb     13 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Map pter - IFN1@ - CDKN2A - CDKN2B - D9S1870 - D9S171 - D9S1679 - D9S265 - D9S259 - PLAA - cen
Authors Beatty (99)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
14 - 4954 87.1 795 - 1999 10644453
13 - 4808 - 772 - 1999 10644453
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunespleen   highly
 thymus   highly
Reproductivefemale systemuteruscervix highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • WD40 repeat motifs at the N terminus
  • three different protein kinase consensus domains
  • a core domain from the PLAA family ubiquitin-binding region of human PLAA (AAs 386-465, namely PFUC) that can bind Ub
  • HOMOLOGY
    interspecies ortholog to yeast Doa1/Ufd3
    Homologene
    FAMILY
  • beta transducin protein superfamily
  • WD repeat PLAP family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • signaling molecule that regulates the production of prostaglandins (PGE(2)) and tumor necrosis factor (TNF1)
  • required for 1alpha,25(OH)2D3 signaling in growth plate chondrocytes
  • specific activator of PLA2 in growth plate chondrocytes, and may mediates the membrane effect of 1alpha,25(OH)2D3, thereby modulating physiological response
  • is required for ubiquitin-dependent trafficking of receptors from early to late endosomes/multivesicular bodies (MVBs)
  • conserved role for mammalian PLAA in Ub-mediated trafficking of membrane proteins though the endolysosomal pathway, and it is essential for mammalian embryonic development
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • is required for 1alpha,25-dihydroxyvitamin D3 dependent rapid activation of protein kinase C via PDIA3
  • PLAA is located in caveolae, where it interacts with PDIA3 and CAV1 to initiate rapid signaling via CAMK2A, CAMK2B
  • VCP/p97 cooperates with YOD1, UBXN6 and PLAA to drive clearance of ruptured lysosomes by autophagy
  • cell & other
    REGULATION
    induced by TNF-alpha can perpetuate inflammation by enhancing activation of PLA(2) and NF-kappaB
    ASSOCIATED DISORDERS
    corresponding disease(s) PLAAND
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Plaa-null mice were perinatal lethal with reduced brain levels of prostaglandin E2