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FLASH GENE
Symbol GTPBP1 contributors: mct/npt - updated : 20-03-2024
HGNC name GTP binding protein 1
HGNC id 4669
DNA
TYPE functioning gene
STRUCTURE 27.00 kb     12 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
12 - 4905 72.5 669 - Olsen (2006)
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
Lymphoid/Immunelymph node   highly
Nervousbrain   highly Homo sapiens
 brainbasal nucleiputamen   Homo sapiens
 brainhindbraincerebellum   Homo sapiens
Visualeye   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularsmooth  highly
Nervouscentral  highly Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/Immunemacrophage
Nervousneuron
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a putative guanosine-triphosphate (GTP)-binding domain
  • HOMOLOGY
    interspecies homolog to murine GP-1
    homolog to C.elegans AGP-1,CGP-1
    Homologene
    FAMILY
  • G protein family
  • peptidyl-elongation factors
  • CATEGORY signaling , receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • encoding a putative GTPase structurally related to peptidyl elongation factors
  • GTPBP1 modulates mRNA degradation via GTP-binding-dependent target loading
  • is likely a regulator and adaptor of the exosome-mediated mRNA turnover pathway
  • possesses EEF1A-like elongation activity, delivering cognate aminoacyl-transfer RNA (aa-tRNA) to the ribosomal A site in a GTP-dependent manner
  • GTPBP1 functions as an important quality control mechanism during translation elongation
  • required to relieve ribosome stalling and maintain neuronal homeostasis
  • GTPBP1 and GTPBP2 encode GTP-binding proteins 1 and 2, which are involved in ribosomal homeostasis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by by interferon-gamma
    ASSOCIATED DISORDERS
    corresponding disease(s) NDEEF2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS