basic FUNCTION
| encoding a putative GTPase structurally related to peptidyl elongation factors |
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GTPBP1 modulates mRNA degradation via GTP-binding-dependent target loading |
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is likely a regulator and adaptor of the exosome-mediated mRNA turnover pathway |
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possesses EEF1A-like elongation activity, delivering cognate aminoacyl-transfer RNA (aa-tRNA) to the ribosomal A site in a GTP-dependent manner |
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GTPBP1 functions as an important quality control mechanism during translation elongation |
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required to relieve ribosome stalling and maintain neuronal homeostasis |
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GTPBP1 and GTPBP2 encode GTP-binding proteins 1 and 2, which are involved in ribosomal homeostasis |