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FLASH GENE
Symbol ZNF384 contributors: mct/npt - updated : 25-05-2016
HGNC name zinc finger protein 384
HGNC id 11955
DNA
TYPE functioning gene
STRUCTURE 23.09 kb     10 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Map pter - DXS99 - CD9 - GAPDH - DRPLA - LAG3 - PTMS - GNB3 - PTPN6 - ZNF384 - C1S C1S - C1R C1R - PEX5 - DXS77 - cen
Authors Gene Map (98)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 3286 - 516 - 2006 16510139
10 - 3141 - 516 - 2006 16510139
10 - 2989 - 516 - 2006 16510139
9 - 3069 - 500 - 2006 16510139
9 - 2941 - 500 - 2006 16510139
11 - 2903 - 461 - 2006 16510139
11 - 3251 - 577 - 2006 16510139
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Nervousbrain    
Reproductivefemale systemovary  predominantly
 female systemuterus   
 male systemtestis   
Respiratorylung    
cells
SystemCellPubmedSpeciesStageRna symbol
not specificchondrocyte
Skeletonosteoblast
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a zinc finger domain
  • conjugated MetalloP
    HOMOLOGY
    Homologene
    FAMILY
  • krueppel C2H2-type zinc-finger protein family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    text osteoblast cytoplasm
    basic FUNCTION
  • playing a potential role in the regulation of neurodevelopment or neuroplasticity
  • contributing to the expression of type I collagen and many of the matrix metalloproteinase gene
  • zinc finger transcription factor with nucleocytoplasmic shuttling activity
  • might be a mediator of the negative feedback loop of collagen synthesis
  • is a key regulator of ribosome biogenesis and the UPR, which together play a central role in determining cell viability during endoplasmic reticulum stress
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • bind and regulate the promoters of MMP1, MMP3, MMP7 and COL1A1
  • interacts with C-propeptides of type I collagen and this association takes place in nuclei
  • binds Zyxin, PCBP1, and vimentin, MMP13
  • PPP1R15A expression is regulated through the activity of the zinc finger transcription factor NMP4 (ZNF384)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion translocation    
    t(12;17) and t(12;22) fuse ZNF384 to RNA-binding proteins TAF15 and EWSR1, while a translocation t(12;19) generates an E2A/ZNF384 fusion, in acute lymphoblastic leukemia
    constitutional     --low  
    loss of ZNF384 resulted in an increase in MYC and PPP1R15A expression that facilitated enhanced ribosome biogenesis and global protein synthesis
    tumoral fusion      
    EP300-ZNF384 fusion transcript, which is a recurrent alteration in B cell acute lymphoblastic leukemia
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS