SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
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| intracellular,cytoplasm,organelle,Golgi
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| intracellular,cytoplasm,organelle,endosome
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| intracellular,cytoplasm,cytosolic
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basic FUNCTION
| regulating neurite extension through association with the TrkA receptor and N-Shc and CrkL/Crk adapter molecules |
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may regulate dendritic spine morphology and strength by modulating Rho GTPases |
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involved in the synaptic adhesion- and N-methyl-D-aspartate-mediated organization of cytoskeletal networks and signal transduction |
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involved in the regulation of neurite outgrowth by exerting its RhoGAP activity and its cellular activity may be regulated through interaction with Src-like tyrosine kinases |
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beta-catenin-interacting GTPase-activating protein (GAP) for CDC42, mediates ER-to-Golgi transport of the N-cadherin/beta-catenin complex |
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required for ER-to-Golgi transport of the fibroblast growth factor-receptor 4 (FGFR4) associated with N-cadherin |
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its activity increased in the presence of PTPRS leading to attenuated RAC activity |