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FLASH GENE
Symbol AP1M1 contributors: mct - updated : 03-09-2012
HGNC name adaptor-related protein complex 1, mu 1 subunit
HGNC id 13667
DNA
TYPE functioning gene
STRUCTURE 37.49 kb     12 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 - 2409 49.7 435 - 1999 10640811
12 - 2373 48.4 423 - 1999 10640811
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
cells
SystemCellPubmedSpeciesStageRna symbol
 polarized cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer heteromer , tetramer
HOMOLOGY
Homologene
FAMILY
  • adaptor complexes medium subunits family
  • CATEGORY adaptor , transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,lysosome
    intracellular,cytoplasm,cytosolic,vesicle
    basic FUNCTION
  • protein sorting from the Golgi network or plasma membrane to lysosomes through the recongnition of tyrosine sorting signals
  • linking clathrin to receptors in coated vesicles
  • mediating basolateral targeting in epithelial cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS endocytosis transport , cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
  • constituent of clathrin-coated vesicles
  • heterotetrameric adaptor complex AP-1 with AP1G, AP1M1/M2, AP1S1/2
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with SLC4A1 (AP1M1 is involved in the SLC4A1 trafficking of kidney alpha-intercalated cells)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS