basic FUNCTION
| embryonic transcriptional regulator |
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forkhead transcription factor that is a primary regulator of melanoblast differentiation in the embryonic neural crest |
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controls the lineage choice between neural/glial and pigment cells by repressing MITF during the early phase of neural crest migration |
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stemness factor that prevents the production of melanocyte progenitors from the developing neural crest |
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having a role as a negative cell cycle regulator |
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FOXD3 and PAX3 act together to affect survival and maintenance of cardiac neural crest progenitors |
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its expression downregulates migration and invasion in melanoma cells and RND3, a target known to be involved in these properties |
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required for maintenance and self-renewal of several diverse progenitor cell lineages |
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TFAP2A and FOXD3, in addition to their respective roles in the differentiation of neural crest derivatives, also jointly maintain the balance of BMP and WNT signaling in order to delineate the neural crest induction domain |
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crucial roles played by FOXD3 during enteric nervous system development including progenitor proliferation, neural patterning, and glial differentiation |
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is an important stem cell factor expressed in many types of embryonic cells including neural crest cells |
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promotes cranial neural crest EMT by eliciting TSPAN18 downregulation separable from its TSPAN18-independent activity during neural crest specification and survival |