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FLASH GENE
Symbol BRPF3 contributors: mct/npt/pgu - updated : 01-12-2012
HGNC name bromodomain and PHD finger containing, 3
HGNC id 14256
DNA
TYPE functioning gene
STRUCTURE 36.02 kb     13 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 - 6054 135.6 1205 - 1999 10574461
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two PHD fingers, for potential interactions with histones
  • a motif called PZPM (PHD/Zn-knuckle/PHD Motif)
  • a bromodomain
  • a PWWP domain
    • HOMOLOGY
    intraspecies homolog to perigrin
    Homologene
    FAMILY
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • bridge the association of MYST3 and MYST4 with ING5 and MEAF6
  • play a key role in assembling and activating MYST3/MYST4 acetyltransferase complexes
  • scaffold component in a couple of histone acetyltransferase (HATs) complexes
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • MYST3 and the related factor MYST4 form tetrameric complexes with ING5 (inhibitor of growth 5), MEAF6 (Esa1-associated factor 6 ortholog), and the bromodomain-PHD finger protein BRPF1, -2, or -3
  • subunit of the KAT6A/KAT6A H3 HAT complex
    • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
    • protein
  • BRPF1, BRD1, BRPF3 bridge the association of KAT6A and KAT6B with ING5 and MEAF6
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS